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Vol. I, No. 6Sugaring / Spring EquinoxMar. 16th, 2001

Health & Medicine
Focus On ...

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The Change
Menopause in the 21st Century, Part 2

In Part I we examined the physiological and psychological changes that accompany the menopausal transition.  Without question these changes can be uncomfortable and can sometimes undermine a woman’s health.  ...

In Part II, we’ll look at some of the preventive and therapeutic approaches to menopause.  But let’s start by reviewing what our bodies naturally do to mitigate the effects of menopause.

Inner hormone replacement
Although most of a woman’s reproductive hormones are produced by the ovaries, other parts of the body chip in.  These include the adrenal glands (which produce our fight-or-flight adrenaline), the pineal gland, skin and fat cells.  (That’s one reason very thin women are more likely to have osteoporosis and other menopausal problems)  As the ovaries produce less, production of hormones at these sites doubles.  According to Christiane Northrup, M.D., in Women’s Bodies, Women’s Wisdom, “Such menopausal problems are due in part to chronic depletion of women’s metabolic resources during the perimenopausal years.  The ease of transition into this stage depends upon the strength of a woman’s adrenals and the state of her general nutrition.  In a healthy woman, the adrenal glands will be able to gradually take over hormonal production from the ovaries.”

Northrop believes that “adrenal health” can help reduce menopausal symptoms and recommends stress management, reduction of sugar and caffeine and vitamin supplements to support adrenal function.  Adrenal production will also continue to diminish with aging, but later and more gradually than ovarian production.

The role of exercise
Many studies document the obvious:  exercise will make you feel better.  These studies show improved mood with aerobic exercise.  But they also suggest that exercise can have more long lasting benefits related to menopause.  Bone density has been shown to increase with weight bearing exercise (swimming doesn’t do it).  Weight bearing exercise also reduces insulin resistance, a condition which can contribute to heart disease.

A 1998 Swedish study published in Maturitas found that “fewer physically active women had severe vasomotor symptoms,” in other words, hot flashes.  They theorized that “physical exercise on a regular basis affects neurotransmitters which regulate central thermoregulation.”

It’s been widely accepted that weight gain is a symptom of menopause, but a recent study published in Menopause 2000 by New England Research Institutes challenges this assumption.  This finding suggests that exercise can also address the weight gain experienced by many menopausal women.

Nutrition
Most of the focus on nutrition for menopause has been related to osteoporosis.  It is widely documented that calcium intake can help slow down bone density loss.  In Nutrition, Osteoporosis and Aging the authors point out the importance of Vitamin D as well.  “Vitamin D (sometimes called a nutrient and sometimes a hormone) is important because age-related vitamin D deficiency leads to malabsorption of calcium, accelerated bone loss, and increased risk of hip fracture.  Vitamin D supplementation has been shown to retard bone loss and reduce hip fracture incidence in elderly women.”

This same study found that salt and protein increased the loss of calcium from bones.  “Protein is another negative risk factor; increasing animal protein intake from 40 to 80 g daily increases urine calcium by about 1 mmol/day.  Low protein intakes in third world countries may partially protect against osteoporosis."  But other studies, of course, are contradictory.  A study published in American Journal of Clinical Nutrition [1999] concluded that “Intake of dietary protein, especially from animal sources, may be associated with a reduced incidence of hip fractures in postmenopausal women.”

Good nutrition guidelines for overall health apply to menopausal women as well.  Smoking and excessive alcohol consumption increase the risk for osteoporosis as well as other illnesses.  And the fruits and vegetables that are thought to help prevent some cancers, heart disease and diabetes have been shown to improve bone health also

Herbs
Herbal remedies have been used to treat menopause for centuries in Western and Eastern cultures, but most have not been tested in controlled studies in this country.

Black cohosh is one herb that has been studied.  In her Use of Alternative Medicine in Women's Health, Lynn Limon explains, “Triterpene glycosides or saponins, including the xylosides actein, 27-deoxyactein, and cimicifugoside, are the primary active constituents of black cohosh and are found in the rhizome and root.  It has estrogen-like action and is a progesterone precursor.  Clinical data support the use of black cohosh for menopausal problems for at least 6 months”

Healthnotes, an online site providing information about complementary medicine reports, “German clinical studies support the usefulness of black cohosh for women with hot flashes associated with menopause.  A review of eight trials concluded black cohosh to be both safe and effective.  Recently, a clinical study compared the effects of 40 mg versus 130 mg of black cohosh in menopausal women with complaints of hot flashes.  While hot flashes were reduced equally at both amounts, there was no evidence of any estrogenic effect in any of the women.  Black cohosh is therefore reserved only for the symptomatic treatment of hot flashes associated with menopause and is not thought to be a substitute for hormone replacement therapy in menopausal and postmenopausal women.”

Limon adds, “Adverse effects of black cohosh include nausea, vomiting, dizziness, nervous system and visual disturbances, and reduced heart rate.  Because it contains salicylic acid and an anticoagulant, black cohosh may interact with salicylates or salicylic acid-containing herbs and any anticoagulant-containing substance and can cause increased bleeding or affect platelet aggregation.”

Like prescription drugs, then, herbal medicines should be taken under the guidance of a qualified healthcare provider.

Plant estrogens
Even the simple soybean is not immune from controversy.  Several plants, particularly soybeans, contain plant hormones called phytoestrogens.  Flaxseed and most fruits and vegetables also have phytoestroges.  These are thought to have a weak estrogen effect when eaten or taken in a supplement.  Studies, though, have not come up with a definitive answer about how or if soybeans help alleviate menopausal symptoms.

Healthnotes reported, “In one double-blind trial, 60 grams of soy protein caused a 33% decrease in the number of hot flashes after four weeks and a 45% reduction after 12 weeks.  However, in further analysis of the data in this trial, researchers now believe constituents in soybeans other than phytoestrogens must have been responsible for the therapeutic effect.  Double-blind evidence from other researchers has also shown significant reduction in the number of hot flashes.  In one randomized trial, high intake of phytoestrogens from soy and flaxseed reduced both hot flashes and vaginal dryness, but much (though not all) of the benefit was also seen in the control group."

In "Phytoestrogens as Therapeutic Alternatives to Traditional Hormone Replacement in Postmenopausal Women," the authors conclude that there is no evidence to show that phytoestrogens reduce cardiovascular disease or osteoporosis in a “manner comparable with HRT." (hormone replacement therapy).  But they do say, “Human data regarding the hormones' ability to alleviate menopausal symptoms, their potential reduction in breast cancer risk, and potential increase in BMD are positive.  These compelling data, in conjunction with absence of information regarding dosing and long-term effects, should serve as stepping stones for further research evaluating phytoestrogens as alternatives or adjuncts to conventional HRT."

Complementary therapies
Research about traditional and complementary medicine is in its infancy in this country.  The National Institutes of Health’s Center for Complementary Health has only recently funded research on therapies like acupuncture and traditional Chinese Medicine, herbs, homeopathy, yoga therapy and others.

Acupuncture, for example, has been used traditionally to treat symptoms of menopause.  The National Institutes of Health indicates at its Complementary Medicine site that the World Health Organization has listed menopause as one of the 40 conditions that may be treated by acupuncture.

Yoga has also been used therapeutically to address menopause symptoms.  Yogic breathing techniques address hot flashes as well as providing stress reduction.  The Canadian Consensus Conference on Menopause and Osteoporosis agrees that, “Both regular aerobic exercise and deep breathing exercises (slow-paced respiration at six breaths/minute) may result in a 40 to 50% reduction in hot flushes."  Because yoga postures are thought to affect both the nervous and the endocrine system, yoga may be used to alleviate perimenopausal anxiety and sleep disturbances and to strengthen adrenal function.

Hormone replacement
Hormone replacement is the medical replacement of either just estrogen (ERT) or a combination of hormones (HRT), which may include estrogen, progesterone, DHEA and testosterone.  Whether to use HRT, and if so, how, is not only a complex, but a controversial question.  Rule number one is to work with a healthcare provider whom you trust.

As we learned in Part I of this article, some symptoms of the menopausal transition are simply uncomfortable, some may undermine quality of life and some may. undermine health and longevity.  Cardiovascular disease is the number one cause of death in women in this country.  It had been thought that replacing estrogen would prevent cardiovascular disease, but more recent studies have clouded this issue.

Desiree Lie, M.D., reports in her comprehensive Hormone Replacement Therapy: Current Evidence and Practice, “More than 30 observational studies (the majority but not all) have reported that ERT or cyclic HRT is associated with a reduced risk of coronary heart disease (CHD) in postmenopausal women.  The clinical implication of these studies is that HRT may be effective for primary prevention of CHD in menopausal women."  A recent large study (the HERS study) shows an increase in secondary “cardiovascular events” like heart attacks in women taking HRT.  Dr. Lie says that, “…HRT is associated with an increase in the frequency of cardiac events during early months of treatment, followed by a reduction in incidence over the long term."

HRT has been associated with an increased risk in uterine and breast cancer.  Combining progestin with estrogen is thought to reduce the risk of uterine cancer, but not breast cancer.  “A number of recent studies on combination therapy provide evidence that the addition of progestin to estrogen does not reduce and may even increase the risk of breast cancer,” says Lie.  She has found that, “A significant amount of data supports an increase in breast-cancer risk with long-term hormone use.  Recently, a large epidemiologic study revealed a trend of increasing breast-cancer risk with duration of HRT use in women.”

Preliminary research in HRT use has suggested that estrogen replacement may help prevent Alzheimer’s disease and even diabetes, as well.  And estrogen applied as a vaginal cream has been shown to effectively treat vaginal atrophy and associated urinary tract infections and, perhaps, postmenopausal urinary incontinence.

Probably the most important concept to take away from the extensive and often confusing information on HRT is that studies continue to challenge previously held assumptions and that HRT is becoming a more and more finely tuned therapy.  Just as each woman has her own, unique physiological and psychological response to the menopause transition, each woman also has her own set of health risks and strengths that figure into the decision about HRT.

Is knowledge power?
Sometimes it seems that our grandmothers were better off.  They went through menopause, had little information and fewer choices about what to do about it, and that was that.

But this is an era in which scientists have begun to decipher the genetic code.  What was unimaginable to our grandmothers is now commonplace. We can even ask, “Can medicine slow down or prevent aging?”  We have options.  And with those options come not only risks, but fundamental questions. 

  • What is “natural” and is it always preferable?
  • How much do the marketing campaigns of drug companies frighten women about menopause?
  • What does it mean to “embrace” menopause and aging?
  • How much do the stresses on women in their perimenopausal years impact their experience of the menopausal transition?
  • How much difference can lifestyle—diet, smoking, medications, exercise, meditation—make?

Medicine in this country may be scientific, but it isn’t necessarily objective.  When we hear the results of research, it’s important to identify the questions that the research answers.  Who was looking for what ... and why?  In that light, scientific knowledge can be power only when it comes along with a willingness to question. 

Every woman knows her own body in her own way.  That is a different kind of knowledge, and that knowledge can be power, too.

Laura Wisniewski     

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Lou Colasanti, Editor & Laura Wisniewski, Associate Editor
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